C. difficile and Antibiotic Resistance
I am currently taking BIOL 676, Genetics of Microorganisms with Dr. Revathi Govind. During this class, we've gotten to learn a little bit about her research on Clostridium difficile. Commonly referred to as C. diff , this bacteria is gram-negative, anaerobic, spore-forming, and identified as one of the most prevalent causes of nosocomial antibiotic-associated diarrhea and colitis (Govind, et al. 2020). These spores reside within the large intestine as part of the microbiome, but are inactive in the presence of a normal gut microbiome. However, oftentimes in hospital settings, when patients are prescribed broad-spectrum antibiotics the normal gut microbes are killed off allowing the C. diff spores to germinate into vegetative C. difficile cells and begin wreaking their havoc. When the spores become viable cells, they begin to release toxins into their environment known simply as toxin A and toxin B, which target the epithelial cells of the inner intestinal wall, causing damage, and