Mutation Rates - Module 4
The idea that mutation rates can evolve shatters the predisposition that mutations are entirely random. However, environmental factors can certainly act on the evolution of mutations and their frequency throughout a population. According to Lynch et al., the evolution of mutation rates depends on three main factors: first, the production rate of a deleterious mutation in a population, second, the reduction in fitness of each mutation, and third, the heritablity or persistence of that mutation through generations (2016). Consider a scenario where a natural disaster randomly wipes out a significant amount of a species' population. Through this event of genetic drift, we can imagine that the variation and mutation frequency in the species would be fairly high; thus, this has become a perfect population for selection to act on. As selection acts against the force of genetic drift, the mutation rate will decrease until an equilibrium is reached over time. This is displayed by the red an...